Even Without Anemia, Iron May Help Fatigue

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NEW YORK (BNA): Some women with unexplained fatigue may get a bit more pep from iron supplements - even if they do not have full-blown anemia, a new clinical trial suggests.

The study focused on women who were chronically tired and had relatively low iron stores. They did not, however, have full-blown iron-deficiency anemia, in which the body has too few oxygen-carrying red blood cells.

It has not been clear whether iron supplements can help battle fatigue in non-anemic women.

To find out, Swiss researchers randomly assigned 200 women with unexplained fatigue to take either 80 milligrams of iron a day or a placebo (identical-looking pills with no active ingredient.)

Over 12 weeks, both groups improved. But women on iron supplements fared better, the researchers report in the Canadian Medical Association Journal.

On average, scores on a standard measure of fatigue fell by nearly half - from about 25 to 13, on a scale of zero to 40 - among women getting the extra iron.

That compared with a 29 percent decline in fatigue reported by the placebo group, whose average score fell from about 25 to just over 16.

The findings suggest that when a woman's persistent fatigue cannot be explained by any health condition, low iron should become a suspect, according to lead researcher Paul Vaucher, a doctoral candidate at the University of Geneva in Switzerland.

Physicians often test for iron deficiency by measuring blood levels of hemoglobin, a protein in blood cells that carries oxygen. But hemoglobin levels usually don't fall until the later stages of iron deficiency, when a person has full-blown anemia.

In their study, Vaucher's team measured women's blood levels of ferritin, which is a marker of the body's stored iron. Doctors may or may not order that test when looking for iron deficiency.

Vaucher said that for a woman with unexplained fatigue, measuring ferritin would be wise.

"This marker will then give a better idea of whether iron load is low or not, even if women are not anemic," Vaucher said in an email.

All of the women in this study had ferritin levels below 50 micrograms per liter, which would be considered low to borderline-low.

Since women in the placebo group also improved, the effects of the iron supplement were not huge. They amounted to an extra 3.5 point shaved off a woman's fatigue score.